Collagen is a cornerstone in nutricosmetic solutions, holding a prominent place in the Asia-Pacific market, with Sirio spotting a need for collagen peptides with a higher standard of proof. The company looks beyond molecular weight to distinguish ingredients with specificity, bioavailability, and clinical validation.
Even Zhang, head of Product Solutions at Sirio APAC, says “Across Asia-Pacific, consumer awareness for collagen is very high, especially among Gen Z and Millennial shoppers.”
Sirio meets demand for more advanced collagen solutions, driven by a growing beauty-from-within market, by drawing on its in-house technology, strict quality control, and clinical validation capabilities.
Shanlu Liang, senior ingredient innovation scientist at Sirio, highlights the company’s Targeted Biotransformation Technology as a key differentiator, which powers the company’s Peptivator technology.
This technology produces specific active peptides with a molecular weight of 300 daltons, boosting their bioavailability 1.5–3 times higher than conventional collagen peptides.
Liang explains that Peptivator standardizes five peptide sequences that account for at least 5% of the ingredient profile.
These standardized peptides are important in hyaluronic acid synthesis, collagen production, cellular hydration, and reactive oxygen species clearance, and Liang cautions that molecular weight alone cannot guarantee biological function.
They note that random hydrolysis of collagen produces many different peptides, making targeted separation essential, and that “peptide identity matters because each sequence triggers a distinct mechanism.”
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The five standardized peptides play an important role in boosting hyaluronic acid synthesis, collagen production, and cellular hydration, as well as reactive oxygen species clearance.
Sirio uses a multi-layer clinical proof system to validate Peptivator, which includes in vitro and in vivo testing, randomized clinical trials, and validating both raw ingredients and finished formulations.
A Caco-2 cell model study compared Peptivator against six commercial collagen peptides, demonstrating a transport rate of 18.5%, establishing that the specific active peptides are absorbed at the cellular level.
A mechanistic study in the roundworm Caenorhabditis elegans explained how identified sequences function biologically.
Sirio is exploring Peptivator‘s usage across more formulation and format options, aiming to deliver more targeted skin benefits for diverse consumer needs.
The company is also developing a new global production base in Chonburi, Thailand, which will deliver tailored, localized supply and innovation services in the region.
Alex Du, general manager at Sirio APAC, notes that the new facility will strengthen support for APAC beauty-supplement brands across product development, manufacturing agility, and time-to-market performance.
