SYMPATHETIC EFFECT OF EUPHORBA HIRTALINN ON THE GASTROINTESTINAL TRACT IN RABBITS
Akomas Stella Chinonye and Ijioma Solomon Nnah.
Department of Veterinary Physiology, Pharmacology, Biochemistry and Animal production, Michael Okpara University of Agriculture, Umudike, Nigeria.
Accepted June, 2014
This study investigated the effect on amplitude and number of rhythmic contractions of ethanolic extract of Euphorbia hirta Linn on the gastrointestinal tract using the rabbit jejunum, so as to ascertain its safety as feed and to investigate the claim of its usefulness in the management of asthma. The effect of the extract on isolated rabbit jejunum was compared to those of standard parasympathomimetic and sympathomimetic drugs including Acetylcholine and Noradrenaline. Fasted Rabbits were euthanized by stunning and the jejunum was carefully isolated. 2 – 3cm of this tissue was cut and mounted in a 35cm3 organ bath supplied with oxygen and maintained at 370C. Graded doses of Acetylcholine, Noradrenalin and Euphorbia hirta Linn extract were administered at different times. The entire procedure was repeated 5 times to obtain mean Amplitudes and number of contractions per minute. Acetylcholine increased Amplitude and number of contractions while noradrenaline reduce same. The extract of Euphorbia hirta Linn exhibited the same effect as that of noradrenaline which suggested that the extract may have bound to adrenergic receptors. This sympathomimetic effect of Euphorbia hirta Linn extract may be the rationale for its use in Asthma management.
Key words: Euphorbia hirta, Acetylcholine, Adrenaline, Adrenergic, Sympathomimetic, Amplitude, Jejunum