MEDICINAL SCIENCES JOURNALS . ISSN 2135-6848

ACUTE TOXICITY STUDY AND HORMONE PROFILE ENHANCING ACTIVITY OF Pausinystalia yohimbe BARK POWDER (BURANTASHI) IN INVIVO EXPERIMENTAL ANIMAL MODELS

Ogwo,E.U.1, Osim, E.E.1,2, Nwankwo, A.A.1, Ijioma, S.N.1,3, Ngwu, E.E1,4

 


ACUTE TOXICITY STUDY AND HORMONE PROFILE ENHANCING ACTIVITY OF Pausinystalia yohimbe BARK POWDER (BURANTASHI) IN INVIVO EXPERIMENTAL ANIMAL MODELS

Department of Human Physiology, Faculty of Basic Medical and Health Sciences, Abia State University, Uturu, Nigeria1
Department of Physiology, College of Medical Sciences, University of Calabar, Cross River, Nigeria2
Department of Physiology and Pharmacology, College of Veterinary Medicine, Michael Okpara University of Agriculture, Umudike, Nigeria3
Department of Human Physiology, College of Medicine, Imo State University, Owerri, Nigeria4

Accepted April 2016.


ABSTRACT

The acute toxicity and effects on hormone profile and testicular weights of Pausinystalia yohimbe, Burantashi bark powder (BBP) was evaluated in groups of adult mice assigned varying doses of BBP extract and male wistar rats administered graded concentrations of the powder in combination with feed in the order 2%, 4%, 6%, 8% and 10% for thirty days. Results obtained indicate an acute toxicity value of 1075mg/kg body weight with deaths occurring in some groups of the treated mice. Significant (P<0.05) and dose dependent increase in testicular weights and hormone levels were also observed with 10% burantashi-feed combination raising testosterone, follicle stimulating hormone and luteinizing hormone levels from 5.25±0.27mg/ml, 0.77±0.03mIU/ml, and 9.38±0.58mIU/ml respectively in the control to 9.40±0.54ng/ml, 1.41±0.02mIU/ml and 21.19±1.13mIU/ml respectively. Similar results were also obtained following treatment with lower concentrations of burantashi except for follicle stimulating hormone which was not significantly affected. In conclusion, the results suggest that burantashi could be lethal at doses beyond 1000mg/kg but may be used are low to moderate doses to enhance reproductive activities in males since the functional integrity of the male reproductive organs depends on adequate bioavailability of testosterone and other male hormones.
KEY WORDS: Burantashi Bark Powder, Follicle Stimulating hormone, Luteinizing hormone, Testosterone