GLUCOSE LEVEL, HAEMATOLOGICAL PARAMETERS AND LIPID PROFILE IN FICUS SUR TREATED DIABETIC RATS.
AKOMAS STELLA CHINONYE1, OKAFOR ANTHONY IKECHUKWU2, IJIOMA SOLOMON NNAH1, 2
1 Department of Physiology, Pharmacology, Biochemistry and Animal Health, College of Veterinary Medicine, Michael Okpara University of Agriculture, Umudike, Abia State, Nigeria.
2 Department of Animal and Environmental Biology, Faculty of Biological and Physical Sciences, Abia State University, Uturu, Nigeria.
Accepted July, 2014
This work was designed to study the effects of ethanol extract of Ficus sur leaves on glucose level, haematological parameters and lipid profile of Alloxan induced diabetic rats. Acute and sub-acute studies on blood glucose level revealed that 150 and 300 mg/kg of Ficus sur ethanolic leaf extract significantly (P<0.05) lowered blood glucose level in diabetic rats and compared favourably with effect of Glibenclamide (5mg/kg), a standard hypoglycaemic drug. The diabetic rats showed marked reduction in Packed cell volume, Haemoglobin content, Red blood cells count, Mean corpuscular haemoglobin, Mean corpuscular volume, Mean corpuscular haemoglobin concentration and platelets with increased White blood cells counts. These anomalies were all restored to about normal values after 21 days of treatment with Ficus sur leaf extract. The extract significantly (P<0.05) decreased the levels of triglycerides, low density lipoprotein cholesterol, very low density lipoprotein cholesterol and total cholesterol but increased the levels of high density lipoprotein cholesterol in diabetic rats. These results suggest that Ficus sur leaves contain potent hypoglycaemic and hypolipidemic agents capable of reversing hyperglycaemia and haematological abnormalities associated with the pathophysiology of diabetes mellitus.
KEY WORDS: Ficus sur, Haematological, Diabetes mellitus, Glucose, Hypolipidemic, Cholesterol.