Transdermal drug delivery system: Formulation aspects and evaluation
Archana K. Gaikwad
The conventional oral dosage forms have significant setbacks of poor bioavailability due to hepatic first pass metabolism. To improve characters of transdermal drug delivery system (TDDS) was emerged, which will improve the therapeutic efficacy and safety of drugs by specific sites within the body, thereby reducing both the size and number of doses. Skin is an effective medium from which absorption of the drug takes place and enters into systematic circulation over a period of time. The present article reviews the selection of drug candidates and polymers suitable to be formulated as transdermal system, advantages, disadvantages of formulation design and the methods of evaluation.
Key words: Transdermal drug delivery system (TDDS), bioavailability, hepatic first pass metabolism.